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Hi, this is Mark and Gabriele
We are the founders of Patient Led Oncology and The Hacking Cancer Portal. As patient and caregiver, we sought to help solve a problem facing patients today, one of a confusion and stress about what to do (and what not to do) to help improve cancer outcomes.
It's based on six years of collective research, summerised and curated for you. Our intention is not to be focus on any one protocol, we are protocol neutral and pro research, data and science.
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We have done the research so you dont need to
We have spent the last few years, studying outcomes to integrative methods used in oncology. Reading thousands of clinical studies, on topics such as cancer vaccines, diets, supplements, off label drugs, testing and ideas on how to get immunotherapy working for cancer typically deemed resistant. We work with many of the world leaders in integrative oncology who share their knowledge with us.

Join a community of other patients, caregivers andĀ doctors working to improve outcomes for others.
Share experiance and knowledge, meet others going throigh the same experiance, by working as a team we build on each others knowledge.
INTRODUCING...
The Cancer Hacking Portal
Coaching principles to help personalize your cancer journey to best suit your situation,
More than 1000 research articles curated,
A review of all the tests that can help you find the treatments more likely to work for your situation,
A list of practitioners that can help you access treatments and monitor your prognosis,
Explanation of how you can hack immunotherapy to increase the odds it will work for you,
Hundreds of suggestions of things you can do to protect the body.
What you can expect
"Hacking Cancer 0.1" is a patient-led guide, written by patients and caregivers, intended to empower individuals with advanced or metastatic cancer to make informed decisions about integrative treatment options. It offers a comprehensive scientific framework and a toolkit for navigating the confusing landscape of cancer care, drawing on extensive research and over 4,000 studies. The book aims to provide actionable science, including a revolutionary "Endgame Strategy," to help patients to try to improve treatment responses+ and quality of life.
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TOOLS TO HELP YOU NAVIGATE YOUR TREATMENT

latest research on conventional and integrative TREATMENTS
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A Vibrant Community for sharing experiences
Table Of Contents
A book by patients and caregivers
Glossary
Section 1: The endgame for cancer
Section 2: The guiding principles (self empowerment plan)
Section 3: Mastering the tools
Section 4: Hacking Cancer
Section 5: Research for situational cases
Section 6: Reviews of other popular treatments
Conclusion
Case reports
A call to action
Discover More in this video
What will you learn
Unlock the secrets to fighting cancer with HACKING CANCER 0.1, your innovative, patient-led guide to oncology! This online community and guidebook, crafted by patients and researchers, offers a beacon of hope and scientific honesty in a world often clouded by confusion. It's designed for those navigating advanced or metastatic cancer, their caregivers, and anyone seeking to understand integrative oncology more deeply.
Learn how simple thingsĀ could improve treatment outcomes and quality of life. This guidebook reveals strategies and insights onĀ protecting the immune system and potentially enhancing long-term survival outcomes.
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- Learn about the transformative power of the Patient-Led Oncology movement, where informed individuals collectively share evidence-based resources.
- Explore the Endgame Strategy, a dynamic, adaptable approach that integrates advanced Western medicine and innate healing for optimal treatment outcomes.
- Understand how low-dose metronomic chemotherapy can achieve similar or better efficacy with significantly fewer side effects compared to traditional high-dose regimens.
- Discover the impact of a natural substance, which more than doubled survival when combined with a chemotherapy drug in a colorectal cancer study.
- Uncover the potential of a high-dose intravenous natural compound for reduced side effects, and improved quality of life, especially in synergy with hyperthermia.
- See how certain mind-body therapies can rapidly reduce anxiety and depression in advanced cancer patients and potentially influence autoimmune diseases.
- Learn how a specific natural supplement can reduce various side effects from chemotherapy treatments.
- Explore a natural hormone supplement's role in enhancing chemotherapy effectiveness and reducing side effects, leading to improved survival.
- Consider promising studies on a repurposed drug for inducing immunogenic cell death, potentially synergizing with checkpoint inhibitors.
- Find out how a repurposed drug can decrease stress-related biochemical consequences and potentially enhance immunotherapy outcomes.
- Investigate a specific repurposed drug combination, showing anti-cancer properties when combined with chemotherapy.
- Explore Hyperthermia, which, when combined with chemotherapy, has shown significantly longer median overall survival (e.g., 20 months vs. 9 months in pancreatic cancer).
- Learn about Cryoablation, a minimally invasive technique with low side effects that can prime the tumor microenvironment for immunotherapy.
- Discover Neoantigen Cancer Vaccines, which demonstrated a 44% reduction in recurrence for high-risk melanoma when combined with checkpoint inhibitors.
- See how an anti-diabetic drug can improve survival and delay resistance to targeted therapies in certain cancers.
- Understand the quality-of-life benefits and enhanced tumor response from a plant-derived extract in combination with conventional therapies.
- Explore how a class of drugs can modulate the tumor microenvironment by reducing immunosuppressive cells.
- Discover the power of a common dietary oil to significantly reduce chemotherapy-induced Hand Foot Syndrome and systemic inflammation.
- Learn about Fasting and Fast Mimicking Diets for mitigating chemotherapy toxicity, improving quality of life, and potentially triggering stem cell regeneration.
- Harness the power of AI tools, which empower patients to understand complex clinical studies more easily.
This isn't just a guidebook; it's a movement towards becoming your own informed advocate in the fight against cancer.
Join our community and start your journey towards a transformed life today!
Cancer hacking inĀ Video
MEET US AT THE YES TO LIFE ANNUAL CONFERENCE
What's Really Working?
27th September 2025
The Light Auditorium
Friends House
London, UK
08.30 to 17.30
BST UK time
